University of Limerick Institutional Repository

Use of a sensitive multi-sugar test for measuring segmental intestinal permeability in critically ill mechanically ventilated adults: a pilot study

DSpace Repository

Show simple item record

dc.contributor.author Tatucu-Babet, Oana A .
dc.contributor.author Forsyth, Adrienne
dc.contributor.author Udy, Andrew
dc.contributor.author Radcliffe, Jessica
dc.contributor.author Benheim, Devin
dc.contributor.author Calkin, Caroline
dc.contributor.author Ridley, Emma J.
dc.contributor.author Gantner, Dashiell
dc.contributor.author Jois, Markandeya
dc.contributor.author Itsiopoulos, Catherine
dc.contributor.author Tierney, Audrey C.
dc.date.accessioned 2021-04-21T14:07:35Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10020
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 24/03/2022
dc.description.abstract Background Increased intestinal permeability (IP) is associated with sepsis in the Intensive Care Unit (ICU). This study aimed to pilot a sensitive multi‐sugar test to measure IP in critically ill patients in the non‐fasted state. Methods Critically ill mechanically ventilated adults were recruited from two ICUs in Australia. Measurements were completed within three days of admission using a multi‐sugar test measuring gastroduodenal (sucrose recovery), small bowel (lactulose‐rhamnose [L‐R] and lactulose‐mannitol [L‐M] ratios) and whole gut permeability (sucralose‐erythritol [S‐E] ratio) in 24‐hour urine samples. Urinary sugar concentrations were compared at baseline and post‐sugar ingestion, and IP sugar recoveries and ratios were explored in relation to known confounders including renal function. Results Twenty‐one critically ill patients (12 males, median 57 years) participated. Group median concentrations of all sugars were higher following sugar administration; however, sucrose and mannitol increases were not statistically significant. Within individual patients, sucrose and mannitol concentrations were higher in baseline than post‐sugar ingestion in nine (43%) and four (19%) patients, respectively. Patients with impaired (n = 9) versus normal (n = 12) renal function had a higher L‐R ratio (median 0.130 versus 0.047,p = 0.003), a lower rhamnose recovery (median 15 versus 24%,p = 0.007) and no difference in lactulose recovery (median 2.5 versus 2.4%,p = 0.508). Conclusion Small bowel and whole gut permeability measurements are possible to complete in the non‐fasted state, while gastroduodenal permeability could not be measured reliably. For small bowel IP measurements, the L‐R ratio is preferred over the L‐M ratio. Alterations in renal function may reduce the reliability of the multi‐sugar IP test, warranting further exploration. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries Journal of Parenteral and Enteral Nutrition;
dc.relation.uri https://doi.org/10.1002/jpen.2110
dc.rights This is the peer reviewed author version of the following article: Use of a sensitive multi-sugar test for measuring segmental intestinal permeability in critically ill mechanically ventilated adults: a pilot study, 2021, Journal of Parenteral and Enteral Nutrition , which has been published in final form at https://doi.org/10.1002/jpen.2110 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms en_US
dc.subject intestinal permeability (IP) en_US
dc.subject ICU en_US
dc.title Use of a sensitive multi-sugar test for measuring segmental intestinal permeability in critically ill mechanically ventilated adults: a pilot study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/jpen.2110
dc.date.embargoEndDate 2022-03-24
dc.embargo.terms 2022-03-24 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


Browse

My Account

Statistics