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Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk

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Show simple item record O'Súilleabháin, Páraic S. Turiano, Nicholas A. Gerstorf, Denis Luchetti, Martina Gallagher, Stephen Sesker, Amanda A. Terracciano, Antonio Sutin, Angelina R. 2021-04-21T09:04:14Z 2021-04-21T09:04:14Z 2021
dc.description peer-reviewed en_US
dc.description.abstract Personality is associated consistently with mortality hazards, but the physiological pathways are not yet clear. Immune system dysregulation may be one such pathway due to its role in age-related morbidity and mortality. In this preregistered study, we tested whether interleukin-6 (IL-6) and C-reactive protein (CRP) mediated the as sociations between personality traits and mortality hazards. The sample included 957 participants (M ± SD = 58.65 ± 11.51 years; range = 35–86 years) from the Midlife in the United States Survey that had 14 years of follow-up. Higher conscientiousness was associated with lower mortality hazards, with each one standard de viation higher conscientiousness associated with a 35% lower mortality risk. IL-6, but not CRP, partially mediated this association, with IL-6 accounting for 18% of this association in the fully adjusted model. While there was initial evidence that the biomarkers mediated both neuroticism and agreeableness and mortality risk, the indirect effects were not significant when controlling for the sociodemographic variables. Taken together, higher conscientiousness may lead to a longer life partially as a result of lower IL-6. This work highlights the importance of biological pathways that link personality to future mortality risk. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Brain, Behavior, and Immunity;93, pp. 238-244
dc.subject personality en_US
dc.subject mortality en_US
dc.subject interleukin-6 en_US
dc.subject conscientiousness en_US
dc.subject neuroticism en_US
dc.title Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.bbi.2021.01.032
dc.contributor.sponsor Royal Irish Academy en_US
dc.contributor.sponsor National Institute on Aging en_US
dc.relation.projectid 5-PO1-AG20166-04; P01- AG020166 en_US
dc.relation.projectid UL1TR001409 en_US
dc.relation.projectid UL1TR001881 en_US
dc.relation.projectid 1UL1RR025011 en_US
dc.relation.projectid R01AG053297 en_US
dc.relation.projectid R01AG068093 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2985306

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