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Dissecting sex-related cognition between Alzheimer’s disease and diabetes: from molecular mechanisms to potential therapeutic strategies

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dc.contributor.author Ashraf, Ghulam
dc.contributor.author Ebada, Mahmoud Ahmed
dc.contributor.author Suhail, Mohd
dc.contributor.author Ali, Ashraf
dc.contributor.author Uddin, Sahab
dc.contributor.author Bilgrami, Anwar L.
dc.contributor.author Perveen, Asma
dc.contributor.author Husain, Amjad
dc.contributor.author Tarique, Mohd
dc.contributor.author Hafeez, Abdul
dc.contributor.author Alexiou, Athanasios
dc.contributor.author Ahmad, Ausaf
dc.contributor.author Kumar, Rajnish
dc.contributor.author Banu, Naheed
dc.contributor.author Najda, Agnieszka
dc.contributor.author Sayed, Amany A.
dc.contributor.author Albadrani, Ghadeer M.
dc.contributor.author Abdel-Daim, Mohamed M.
dc.contributor.author Peluso, Ilaria
dc.contributor.author Barreto, George E.
dc.date.accessioned 2021-04-20T10:59:21Z
dc.date.available 2021-04-20T10:59:21Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10012
dc.description peer-reviewed en_US
dc.description.abstract The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer’s disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains. en_US
dc.language.iso eng en_US
dc.publisher Hindawi en_US
dc.relation.ispartofseries Oxidative Medicine and Cellular Longevity;article 4572471
dc.subject Alzheimer's disease en_US
dc.title Dissecting sex-related cognition between Alzheimer’s disease and diabetes: from molecular mechanisms to potential therapeutic strategies en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1155/2021/4572471
dc.contributor.sponsor Deanship of Scientific Research at Princess Nourah bint Abdulrahman University en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2993527


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