University of Limerick Institutional Repository

Browsing Departments Science and Engineering by Subject "zinc"

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Browsing Departments Science and Engineering by Subject "zinc"

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  • De Benedictis, Chiara A.; Raab, Andrea; Ducie, Ellen; Howley, Shauna; Feldmann, Joerg; Grabrucker, Andreas M. (MDPI, 2020)
    The essential trace metals iron, zinc, and copper have a significant physiological role in healthy brain development and function. Especially zinc is important for neurogenesis, synaptogenesis, synaptic transmission and ...
  • Hagmeyer, Simone; Romão, Mariana A.; Cristóvão, Joana S.; Vilella, Antonietta; Zoli, Michele; Gomes, Cláudio M.; Grabrucker, Andreas M. (Frontiers Media, 2019)
    Increasing evidence links proteins of the S100 family to the pathogenesis of Alzheimer’s disease (AD). S100 proteins are EF-hand calcium-binding proteins with intra- and extracellular functions related to regulation of ...
  • De Benedictis, Chiara A.; Vilella, Antonietta; Grabrucker, Andreas M. (2019)
    The extracellular aggregation of insoluble protein deposits of amyloid-β (Aβ) into plaques and the hyperphosphorylation of the intracellular protein tau leading to neurofibrillary tangles are the main pathological hallmarks ...
  • Hagmeyer, Simone; Cristóvão, Joana S.; Mulvihill, John J.E.; Boeckers, Tobias M.; Gomes, Cláudio M.; Grabrucker, Andreas M. (Frontiers Media, 2018)
    Neuronal metal ions such as zinc are essential for brain function. In particular synaptic processes are tightly related to metal and protein homeostasis, for example through extracellular metal-binding proteins. One such ...

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