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Browsing by Author "Somma, Domenico"

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Browsing by Author "Somma, Domenico"

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  • Mitxitorena, Izaskun; Somma, Domenico; Mitchell, Jennifer P.; Lepistö, Matti; Tyrchan, Christian; Smith, Emma L.; Kiely, Patrick A.; Walden, Helen; Keeshan, Karen; Carmody, Ruaidhrí J. (The American Society for Biochemistry and Molecular Biology, 2020)
    The transcription factor NF-kB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines.Ubiquitination-triggered ...
  • Smith, Emma L.; Somma, Domenico; Kerrigan, David; McIntyre, Zoe; Cole, John J.; Ling Liang, Kai; Kiely, Patrick A.; Keeshan, Karen; Carmody, Ruaidhrı J. (Oxford University Press, 2019)
    Phosphorylation of the NF-kB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-kB, and IKKβ as ...