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Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men

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dc.contributor.author Clegg, Miriam E.
dc.contributor.author Shafat, Amir
dc.date.accessioned 2011-04-08T15:41:10Z
dc.date.available 2011-04-08T15:41:10Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10344/999
dc.description peer-reviewed en_US
dc.description.abstract The H2 breath test is ideal for orocaecal transit time (OCTT) measurement, as it is non-invasive and inexpensive. Indigestible substrates added to a test meal are metabolised by the colonic bacteria, resulting in the production of H2 which is detected in end-exhalation breath. However, the substrates themselves can alter the transit times in the gastrointestinal tract. The aim of the present study is to compare OCTT and gastric emptying (GE) when lactulose in liquid (L-L), solid lactulose (L-S) and solid inulin (IN-S) are added to a test meal, and subsequently, to examine if inulin alters GE. Firstly, ten male volunteers were tested on three occasions. Volunteers ate a pancake breakfast containing 100 mg of 13C-octanoic acid and either 12 g of L-L, 12 g of L-S or 12 g of IN-S in a randomised order. Secondly, seven male volunteers were tested twice with meals containing either 12 g of IN-S or no substrate (NO-S). L-L induced the shortest OCTT (85.3 (SD 42.8) min) compared with L-S (162.4 (SD 62.6) min) and inulin (292.4 (SD 66.7) min; P¼0.007). GE half-time and lag phase (L-L: 61 (SD 9); L-S: 57 (SD 10); IN-S: 52 (SD 10) min; P¼0.005) were also affected, with L-L being the slowest. Thirdly, inulin reduced GE lag and latency phases (P,0•05) compared with NO-S. Lactulose accelerates OCTT but delays GE compared with inulin. Inulin accelerates the onset of stomach emptying, but it has no effect on GE half-time. For these reasons, inulin is the preferred substrate for the H2 breath test. en_US
dc.language.iso eng en_US
dc.publisher Cambridge Journals Online en_US
dc.relation.ispartofseries British Journal of Nutrition;104/4/ pp. 554-559
dc.relation.uri http://dx.doi.org/10.1017/S0007114510000905
dc.subject gastric emptying en_US
dc.subject inulin en_US
dc.subject lactulose en_US
dc.subject orocaecal transit time en_US
dc.title Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men en_US
dc.type Article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.internal.authorcontactother amir.shafat@nuigalway.ie


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