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Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men

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dc.contributor.author Clegg, Miriam E.
dc.contributor.author McKenna, Paul
dc.contributor.author McClean, Conor
dc.contributor.author Davison, Gareth W.
dc.contributor.author Trinick, Tom
dc.contributor.author Duly, Ellie
dc.contributor.author Shafat, Amir
dc.date.accessioned 2011-04-07T15:34:00Z
dc.date.available 2011-04-07T15:34:00Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10344/983
dc.description peer-reviewed en_US
dc.description.abstract Background/Objectives: High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety. Subjects/Methods: Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the 13C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H2 breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula. Results: MCTT was different between the three test days (P¼0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. Conclusion: This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days. en_US
dc.language.iso eng en_US
dc.publisher Nature en_US
dc.relation.ispartofseries European Journal of Clinical Nutrition;65/ 240–246
dc.relation.uri http://dx.doi.org/doi:10.1038/ejcn.2010.235
dc.subject gastric emptying en_US
dc.subject lipaemia en_US
dc.subject satiety en_US
dc.title Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men en_US
dc.type Article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.internal.authorcontactother amir.shafat@nuigalway.ie

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