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New approaches to abdominal aortic aneurysm rupture risk assessment - engineering insights with clinical gain

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dc.contributor.author McGloughlin, Timothy M.
dc.contributor.author Doyle, Barry J.
dc.date.accessioned 2010-07-28T09:20:58Z
dc.date.available 2010-07-28T09:20:58Z
dc.date.issued 2010
dc.identifier.citation McGloughlin and Doyle, Arterioscler Thromb Vasc Biol, 2010, doi:10.1161/ATVBAHA.110.204529 en_US
dc.identifier.uri http://hdl.handle.net/10344/437
dc.description peer-reviewed en_US
dc.description.abstract Abdominal aortic aneurysm (AAA) rupture remains a significant cause of death in the developed world. Current treatment approaches rely heavily on the size of the aneurysm to decide on the most appropriate time for clinical intervention and treatment. However, over recent years several alternative rupture-risk indicators have been proposed. This brief review examines some of these new approaches to AAA rupture-risk assessment, from both numerical and experimental aspects and also what the future may hold for AAA rupture-risk. While numerically-predicted wall stress, finite element analysis rupture index (FEARI), rupture potential index (RPI), severity parameter (SP), and geometrical factors such as asymmetry have all been developed and show promise in possibly helping to predict AAA rupture-risk, validation of these tools remains a significant challenge. Validation of biomechanics-based rupture indicators may be feasible by combining in vitro modeling of realistic AAA analogues together with both retrospective and prospective monitoring and modeling of AAA cases. Peak wall stress is arguably the primary result obtained from numerical analyses however, as the majority of ruptures occur in the posterior and posterior-lateral regions, the role of posterior wall stress has also recently been highlighted as potentially significant. It is also known that wall stress alone is not enough to cause rupture as wall strength plays an equal role. Therefore, should a biomechanics-based rupture-risk be implemented? There have been some significant steps, both numerically and experimentally, towards answering this and other questions relating to AAA rupture-risk prediction yet regardless of the efforts underway in several laboratories, the introduction of a numerically-predicted rupture-risk parameter into the clinicians’ decision-making process may still be quite some time away. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.ispartofseries Arteriosclerosis, Thrombosis and Vascular Biology;
dc.relation.uri http://dx.doi.org/10.1161/ATVBAHA.110.204529
dc.subject abdominal aortic aneurysm en_US
dc.subject rupture risk en_US
dc.subject experimental en_US
dc.subject computational en_US
dc.subject new approaches en_US
dc.subject imrpoved treatment en_US
dc.title New approaches to abdominal aortic aneurysm rupture risk assessment - engineering insights with clinical gain en_US
dc.type Journal Article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.contributor.sponsor US National Heart Lung and Blood Institute


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