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Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques

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dc.contributor.author Doyle, Barry J.
dc.contributor.author Cloonan, Aidan J.
dc.contributor.author Walsh, Michael T.
dc.contributor.author Vorp, David A.
dc.contributor.author McGloughlin, Timothy M.
dc.date.accessioned 2010-07-21T14:08:27Z
dc.date.available 2010-07-21T14:08:27Z
dc.date.issued 2010
dc.identifier.citation Barry J. Doyle, Aidan J. Cloonan, Michael T. Walsh, David A. Vorp, Timothy M. McGloughlin, Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques, Journal of Biomechanics, 43(7), pp1408-1416 en_US
dc.identifier.uri http://hdl.handle.net/10344/415
dc.description peer-reviewed en_US
dc.description.abstract In the event of abdominal aortic aneurysm (AAA) rupture, the outcome is often death. This paper aims to experimentally identify the rupture locations of in vitro AAA models and validate these rupture sites using finite element analysis (FEA). Silicone rubber AAA models were manufactured using two different materials (Sylgard 160 and Sylgard 170, Dow Corning) and imaged using computed tomography (CT). Experimental models were inflated until rupture with high speed photography used to capture the site of rupture. 3D reconstructions from CT scans and subsequent FEA of these models enabled the wall stress and wall thickness to be determined for each of the geometries. Experimental models ruptured at regions of inflection, not at regions of maximum diameter. Rupture pressures (mean ± SD) for the Sylgard 160 and Sylgard 170 models were 650.6 ± 195.1 mmHg and 410.7 ± 159.9 mmHg, respectively. Computational models accurately predicted the locations of rupture. Peak wall stress for the Sylgard 160 and Sylgard 170 models was 2.15 ± 0.26 MPa at an internal pressure of 650 mmHg and 1.69 ± 0.38 MPa at an internal pressure of 410 mmHg, respectively. Mean wall thickness of all models was 2.19 ± 0.40 mm, with a mean wall thickness at the location of rupture of 1.85 ± 0.33 mm and 1.71 ± 0.29 mm for the Sylgard 160 and Sylgard 170 materials, respectively. Rupture occurred at the location of peak stress in 80% (16/20) of cases and at a high stress regions but not peak stress in 10% (2/20) of cases. 10% (2/20) of models had defects in the AAA which moved the rupture location away from regions of elevated stress. The results presented may further contribute to the understanding of AAA biomechanics and ultimately AAA rupture prediction. en_US
dc.language.iso eng en_US
dc.publisher Elsevier Science en_US
dc.relation.ispartofseries Journal of Biomechanics;43/7/ pp1408-1419
dc.subject abdominal aortic aneurysm en_US
dc.subject rupture en_US
dc.subject experimental en_US
dc.subject computational en_US
dc.title Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques en_US
dc.type Journal Article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.contributor.sponsor US National Heart Lung and Blood Institute
dc.relation.projectid RS/2005/340
dc.relation.projectid R01-HL-060670

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