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Spherical indentation of free-standing acellular extracellular matrix membranes

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dc.contributor.author Cloonan, Aidan J.
dc.contributor.author O'Donnell, Michael R.
dc.contributor.author Lee, William T.
dc.contributor.author Walsh, Michael T.
dc.contributor.author De Barra, Eamonn
dc.contributor.author McGloughlin, Timothy M.
dc.date.accessioned 2012-03-27T12:10:39Z
dc.date.available 2012-03-27T12:10:39Z
dc.date.issued 2012
dc.identifier.issn 1742-7061
dc.identifier.uri http://hdl.handle.net/10344/2132
dc.description peer-reviewed en_US
dc.description.abstract Numerous scaffold materials have been developed for tissue engineering and regenerative medicine applications to replace or repair damaged tissues and organs. Naturally occurring scaffold materials derived from acellular xenogeneic and autologous extracellular matrix (ECM) are currently in clinical use. These biological scaffold materials possess inherent variations in mechanical properties. Spherical indentation or ball burst testing has commonly been used to evaluate ECM and harvested tissue due to its ease of use and simulation of physiological biaxial loading, but has been limited by complex material deformation profiles. An analytical methodology has been developed and applied to experimental load–deflection data of a model hyperelastic material and lyophilized ECM scaffolds. An optimum rehydration protocol was developed based on water absorption, hydration relaxation and dynamic mechanical analysis. The analytical methodology was compared with finite element simulations of the tests and excellent correlation was seen between the computed biaxial stress resultants and geometry deformations. A minimum rehydration period of 5 min at 37 °C was sufficient for the evaluated multilaminated ECM materials. The proposed approach may be implemented for convenient comparative analysis of ECM materials and source tissues, process optimization or during lot release testing. en_US
dc.language.iso eng en_US
dc.publisher Elsevier Ltd. en_US
dc.relation.ispartofseries Acta Biomaterialia;2012 8(1), pp. 262-273
dc.relation.uri http://dx.doi.org/10.1016/j.actbio.2011.08.003
dc.rights This is the author’s version of a work that was accepted for publication in Acta Biomater. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomater,2012 8(1), pp 262-273.http://dx.doi.org/10.1016/j.actbio.2011.08.003 en_US
dc.subject soft tissue biomechanics en_US
dc.subject decellularized tissue en_US
dc.subject small intestinal submucosa en_US
dc.subject urinary bladder matrix en_US
dc.subject silicone elastomer en_US
dc.subject tissue engineering en_US
dc.subject regenerative medicine en_US
dc.title Spherical indentation of free-standing acellular extracellular matrix membranes en_US
dc.type Article en_US
dc.type Research paper en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.contributor.sponsor EI
dc.contributor.sponsor MACSI
dc.contributor.sponsor SFI
dc.relation.projectid 06/MI/005
dc.internal.rssid 1148330

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