Mathematics & Statistics

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How real is intention-to-treat (ITT) analysis in non-interventional post authorization safety studies? we can do better

Kiri, Victor A; MacKenzie, Gilbert (Bentham Science Publishers, 2009)

Although cohort studies which are based on intention-to-treat (ITT) approach offer a simple design with data which are simpler to analyse and results easier to interpret, such studies also intrinsically assume that any ...
Modelling covariance structure in bivariate marginal models for longitudinal data

Xu, Jing; MacKenzie, Gilbert (Oxford University Press, 2012)

It can be more challenging and demanding to efficiently model the covariance matrices for multivariate longitudinal data than for univariate case because of the correlations between responses arising from multiple variables ...
On the interval estimation of the parameters of a generalized time-dependent logistic model

Louzada-Neto, Francisco; MacKenzie, Gilbert; Cremasco, Caroline Pires; Ferreira-Silva, Paulo Henrique (UNESP, 2011)

In order to accommodating crossing hazard curves, which are non- proportional hazards, we consider in this paper a generalized time-dependent logistic hazard survival model, which has a time-dependent term. The model is ...
The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer

Karpinski, Pawel; Ramsey, David; Grzebieniak, Zygmunt; Sasiadek, Maria Malgorzata; Blin, Nikolaus (American Association for Cancer Research, 2008)
Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype

Karpinski, Pawel; Myszka, Aleksander; Ramsey, David; Kielan, Wojciech; Sasiadek, Maria Malgorzata (Springer-Verlag, 2011)

There is evidence that insertion of viral DNA into a mammalian genome can lead to alterations of methylation patterns. The aim of the present study was to examine the presence of DNA sequences of five human DNA viruses ...

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